Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation
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چکیده
منابع مشابه
Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation
The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells (ECs), the building blocks of islet microvasculature. Intra-islet ECs, ac...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2012
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2012.04.022